MMP9 Genotype and Systemic T-Cell Subsets Correlate With Structural and Functional Outcomes in Neovascular Age-Related Macular Degeneration.

doi:10.1167/iovs.67.6.29

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Article

MMP9 Genotype and Systemic T-Cell Subsets Correlate With Structural and Functional Outcomes in Neovascular Age-Related Macular Degeneration.

Investigative ophthalmology & visual science - 1 Jun 2026

Martinez Thomas L, Zacharias Zeb R, Lee Kyungmoo, Han Ian C, Jiao Chunhua, Bach Bernardo B, Roos Benjamin, Chava Srinivas, McCormick Mary M, Sinkey Christine, Wu Amy P, Mukhopadhyay Chirantan, Coussa Razek G, Russell Jonathan, Binkley Elaine M, Boldt H Culver, Folk James C, Russell Stephen R, Mullins Robert F, Fingert John H, Wang Kai, Abramoff Michael D, Stone Edwin M, Scheetz Todd E, Houtman Jon C D, Sonka Milan, Sohn Elliott H

Abstract excerpt

Purpose: Genetic studies implicate the matrix metalloproteinase-9 (MMP9) locus in neovascular age-related macular degeneration (nvAMD) risk but genotype-phenotype associations of MMP9 with nvAMD are lacking. This study aimed to investigate the influence of MMP9 genotype and T-cell subset frequency on structural and functional treatment outcomes in nvAMD. Methods: We reanalyzed single-cell RNA sequencing data and...

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Identifiers

PMID: 42300675
DOI: 10.1167/iovs.67.6.29
PMCID: PMC13281956

Genes

MMP9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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