MeSCoT: the tool for quantitative trait simulation through the mechanistic modeling of genes' regulatory interactions.

doi:10.1093/g3journal/jkab133

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Article

MeSCoT: the tool for quantitative trait simulation through the mechanistic modeling of genes' regulatory interactions.

G3 (Bethesda, Md.) - 14 Jul 2021

Milkevych Viktor, Karaman Emre, Sahana Goutam, Janss Luc, Cai Zexi, Lund Mogens Sandø

Abstract excerpt

This work represents a novel mechanistic approach to simulate and study genomic networks with accompanying regulatory interactions and complex mechanisms of quantitative trait formation. The approach implemented in MeSCoT software is conceptually based on the omnigenic genetic model of quantitative (complex) trait, and closely imitates the basic in vivo mechanisms of quantitative trait realization. The software...

Topics

Quantitative Trait Loci
Models, Genetic
Gene Regulatory Networks
Epistasis, Genetic
Phenotype

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Open in PubMed Open full text

Identifiers

PMID: 33905502
DOI: 10.1093/g3journal/jkab133
PMCID: PMC8496224

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