Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

MeSCoT: the tool for quantitative trait simulation through the mechanistic modeling of genes' regulatory interactions.

G3 (Bethesda, Md.) - 14 Jul 2021

Milkevych Viktor, Karaman Emre, Sahana Goutam, Janss Luc, Cai Zexi, Lund Mogens Sandø

Abstract excerpt

This work represents a novel mechanistic approach to simulate and study genomic networks with accompanying regulatory interactions and complex mechanisms of quantitative trait formation. The approach implemented in MeSCoT software is conceptually based on the omnigenic genetic model of quantitative (complex) trait, and closely imitates the basic in vivo mechanisms of quantitative trait realization. The software...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Epistasis, Genetic
Share to Gene Regulatory Networks

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Models, Genetic

Share to Phenotype

Share to Quantitative Trait Loci

Source

Open in PubMed Open full text

Identifiers

PMID: 33905502
DOI: 10.1093/g3journal/jkab133
PMCID: PMC8496224

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

MeSCoT: the tool for quantitative trait simulation through the mechanistic modeling of genes' regulatory interactions.PMID 33905502Read ↗

Modeling the genetic architecture of complex traits with molecular markers.Semantic proximity Read ↗

Genetic Causation in Complex Regulatory Systems: An Integrative Dynamic Perspective.Semantic proximity Read ↗

Genome and Environment Based Prediction Models and Methods of Complex Traits Incorporating Genotype × Environment Interaction.Semantic proximity Read ↗

Quantitative omnigenic model discovers interpretable genome-wide associationsSemantic proximity Read ↗

The genomic determinants of genotype × environment interactions in gene expression.Semantic proximity Read ↗

Quantitative omnigenic model discovers interpretable genome-wide associations.Semantic proximity Read ↗

Systems Genetics as a Tool to Identify Master Genetic Regulators in Complex Disease.Semantic proximity Read ↗

QU-GENE: a simulation platform for quantitative analysis of genetic models.Semantic proximity Read ↗

Simulating systems genetics data with SysGenSIM.Semantic proximity Read ↗

The GRN concept as a guide for evolutionary developmental biology.Semantic proximity Read ↗

Integrator networks: illuminating the black box linking genotype and phenotype.Semantic proximity Read ↗

Genotype-phenotype mapping in a post-GWAS world.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.