Gene network and biological pathways associated with susceptibility to differentiated thyroid carcinoma.

doi:10.1038/s41598-021-88253-0

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Article

Gene network and biological pathways associated with susceptibility to differentiated thyroid carcinoma.

Scientific reports - 26 Apr 2021

Kulkarni Om, Sugier Pierre-Emmanuel, Guibon Julie, Boland-Augé Anne, Lonjou Christine, Bacq-Daian Delphine, Olaso Robert, Rubino Carole, Souchard Vincent, Rachedi Frédérique, Lence-Anta Juan Jesus, Ortiz Rosa Maria, Xhaard Constance, Laurent-Puig Pierre, Mulot Claire, Guizard Anne-Valérie, Schvartz Claire, Boutron-Ruault Marie-Christine, Ostroumova Evgenia, Kesminiene Ausrele, Deleuze Jean-François, Guénel Pascal, De Vathaire Florent, Truong Thérèse, Lesueur Fabienne

Abstract excerpt

Variants identified in earlier genome-wide association studies (GWAS) on differentiated thyroid carcinoma (DTC) explain about 10% of the overall estimated genetic contribution and could not provide complete insights into biological mechanisms involved in DTC susceptibility. Integrating systems biology information from model organisms, genome-wide expression data from tumor and matched normal tissue and GWAS data...

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PMID: 33903625
DOI: 10.1038/s41598-021-88253-0
PMCID: PMC8076215

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