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Article

Pan-TRK Immunohistochemistry Is Highly Correlated With NTRK3 Gene Rearrangements in Salivary Gland Tumors.

The American journal of surgical pathology - 1 Nov 2021

Csanyi-Bastien Marie, Lanic Marie-Delphine, Beaussire Ludivine, Ferric Sandra, François Arnaud, Meseure Didier, Jardin Fabrice, Wassef Michel, Ruminy Philippe, Laé Marick

Abstract excerpt

AIMS: Secretory carcinoma (SC) is characterized by ETV6 rearrangements, most often ETV6-NTRK3 fusion. Given its histologic overlap with other salivary gland tumors (SGTs), SCs can be difficult to diagnose without genetic confirmation. A recently developed pan-TRK (tropomyosin receptor kinase) antibody shows promise for identifying tumors with NTRK (neurotrophic tyrosine kinase receptor 3) fusions. The aim of this...

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Identifiers

PMID: 33899788
DOI: 10.1097/PAS.0000000000001718

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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