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Article

VPS13D promotes peroxisome biogenesis.

The Journal of cell biology - 3 May 2021

Baldwin Heather A, Wang Chunxin, Kanfer Gil, Shah Hetal V, Velayos-Baeza Antonio, Dulovic-Mahlow Marija, Brüggemann Norbert, Anding Allyson, Baehrecke Eric H, Maric Dragan, Prinz William A, Youle Richard J

Abstract excerpt

The VPS13 gene family consists of VPS13A-D in mammals. Although all four genes have been linked to human diseases, their cellular functions are poorly understood, particularly those of VPS13D. We generated and characterized knockouts of each VPS13 gene in HeLa cells. Among the individual knockouts, only VPS13D-KO cells exhibit abnormal mitochondrial morphology. Additionally, VPS13D loss leads to either partial or...

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Identifiers

PMID: 33891012
DOI: 10.1083/jcb.202001188
PMCID: PMC8077185

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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