Interaction of testosterone and testosterone receptor complexes with nuclei of skeletal muscle from intact male mice and from mice bearing the testicular feminization (Tfm) mutant gene.

doi:10.1515/znc-1988-3-415

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Article

Interaction of testosterone and testosterone receptor complexes with nuclei of skeletal muscle from intact male mice and from mice bearing the testicular feminization (Tfm) mutant gene.

Zeitschrift fur Naturforschung. C, Journal of biosciences - 1 Jan 2000

Franzelius C, Eisele K

Abstract excerpt

With the nuclear exchange assay and the nuclear retention assay it is shown that the androgen insensitivity of Tfm mice is probably due to a defect of the nuclear acceptor sites for the testosterone receptor complex. Further on the results obtained point strongly to the possibility that hormone free androgen receptor is localized in the nuclei and in the cytoplasma according to the "equilibrium model". A...

Topics

Androgen-Insensitivity Syndrome
Animals
Cell Nucleus
Cytosol
Genes
Kinetics
Male
Mice
Mice, Inbred C57BL
Muscles
Mutation

Receptors, Androgen

Receptors, Steroid

Reference Values

Testosterone

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