Article
Genetic analyses identify widespread sex-differential participation bias.
Nature genetics - 1 May 2021
Pirastu Nicola, Cordioli Mattia, Nandakumar Priyanka, Mignogna Gianmarco, Abdellaoui Abdel, Hollis Benjamin, Kanai Masahiro, Rajagopal Veera M, Parolo Pietro Della Briotta, Baya Nikolas, Carey Caitlin E, Karjalainen Juha, Als Thomas D, Van der Zee Matthijs D, Day Felix R, Ong Ken K, Morisaki Takayuki, de Geus Eco, Bellocco Rino, Okada Yukinori, Børglum Anders D, Joshi Peter, Auton Adam, Hinds David, Neale Benjamin M, Walters Raymond K, Nivard Michel G, Perry John R B, Ganna Andrea
Abstract excerpt
Genetic association results are often interpreted with the assumption that study participation does not affect downstream analyses. Understanding the genetic basis of participation bias is challenging since it requires the genotypes of unseen individuals. Here we demonstrate that it is possible to estimate comparative biases by performing a genome-wide association study contrasting one subgroup versus another....
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