Gene-set distance analysis (GSDA): a powerful tool for gene-set association analysis.

Abstract excerpt

BACKGROUND: Identifying sets of related genes (gene sets) that are empirically associated with a treatment or phenotype often yields valuable biological insights. Several methods effectively identify gene sets in which individual genes have simple monotonic relationships with categorical, quantitative, or censored event-time variables. Some distance-based methods, such as distance correlations, may detect complex...

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