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Chlamydia trachomatis ompA Genotype and Clinical Signs of Trachoma in a Longitudinal Tanzanian Cohort.

Pathogens (Basel, Switzerland) - 4 Jul 2026

Harte Anna J, Mafuru Elias, Ramadhani Athumani, Derrick Tamsyn, Pickering Harry, Mtuy Tara, Massae Patrick, Ghasemian Ehsan, Malissa Aiweda, Bailey Robin L, Mabey David C W, Burton Matthew J, Holland Martin J

Abstract excerpt

Trachoma, caused by Chlamydia trachomatis (Ct), persists as a major cause of preventable blindness despite the global SAFE strategy. Understanding how Ct genovars and genovariants influence infection dynamics and clinical outcomes is crucial for sustaining elimination efforts and informing vaccine development. A four-year longitudinal study was conducted in a trachoma-endemic region of Tanzania across multiple...

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PMID: 42515032
DOI: 10.3390/pathogens15070705
PMCID: PMC13414724

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