Bioinformatic Analysis of Chlamydia trachomatis Polymorphic Membrane Proteins PmpE, PmpF, PmpG and PmpH as Potential Vaccine Antigens.

doi:10.1371/journal.pone.0131695

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Article

Bioinformatic Analysis of Chlamydia trachomatis Polymorphic Membrane Proteins PmpE, PmpF, PmpG and PmpH as Potential Vaccine Antigens.

PloS one - 1 Jan 2015

Nunes Alexandra, Gomes João P, Karunakaran Karuna P, Brunham Robert C

Abstract excerpt

Chlamydia trachomatis is the most important infectious cause of infertility in women with important implications in public health and for which a vaccine is urgently needed. Recent immunoproteomic vaccine studies found that four polymorphic membrane proteins (PmpE, PmpF, PmpG and PmpH) are immunodominant, recognized by various MHC class II haplotypes and protective in mouse models. In the present study, we aimed...

Topics

Amino Acid Motifs
Amino Acid Sequence
Antigens, Bacterial
Bacterial Outer Membrane Proteins
Chlamydia trachomatis
Epitopes
Molecular Sequence Data
Polymorphism, Single Nucleotide

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Identifiers

PMID: 26131720
DOI: 10.1371/journal.pone.0131695
PMCID: PMC4488443

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