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Establishment of primary reference measurement procedures and reference materials for EGFR variant detection in non-small cell lung cancer.

Analytical methods : advancing methods and applications - 13 May 2021

Wang Xia, Zhang Yongzhuo, Niu Chunyan, Wang Shangjun, Li Liang, Guo Yong, Zhu Lingxiang, Jin Xiaohua, Gao Huafang, Xu Wentao, Zhu Pengyu, Lan Qingkuo, Du Meihong, Cheng Xiaoyan, Gao Yunhua, Dong Lianhua

Abstract excerpt

Circulating tumor DNA (ctDNA)-based mutation detection is promising to change the clinical practice of genotype-directed therapy for cancer. A growing number of non-invasive tests for cancer screening and monitoring that involve the detection of ctDNA have been commercialized. Primary reference measurement procedures (PRMPs) and reference materials (RMs) are urgently needed to assess the non-invasive tests. In...

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PMID: 33870958
DOI: 10.1039/d1ay00328c

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