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Development and characterization of nucleosomal DNA-based reference materials for the epidermal growth factor receptor gene liquid biopsy.

Analytical and bioanalytical chemistry - 1 Jun 2026

Hong Sae Rom, Park Jaehyeong, Lee Sang-Soo, Kim Do-Yei, Cho Yong-Joon, Bae Young-Kyung

Abstract excerpt

Liquid biopsy has emerged as a valuable tool in cancer research and diagnosis; however, its clinical utility relies heavily on the accurate detection of low variant allele frequencies (VAFs). Evaluating such sensitivity demands reference materials (RMs) that biologically resemble cell-free DNA (cfDNA) in addition to confirmed basic attributes. Here, we report the development and characterization of a pilot batch...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41936644
DOI: 10.1007/s00216-026-06475-5
PMCID: PMC13221357

Genes

EGFR

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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