Article
Variations in Env at amino acids 328 and 330 affect HIV-1 replicative fitness and entry inhibitor sensitivity.
Virus research - 2 Jul 2021
Wang Hongye, Li Yang, Li Ya, Li Bingxiang, Zhu Xiaoyong, Yan Dongshan, Li Mingyu, Wu Wenying, Sun Ming, Yang Rongge
Abstract excerpt
While the variations in the HIV-1 Env V3 loop have been the focus of much research to explore its functional effect, how specific mutations of certain amino acids in the V3 loop affect viral fitness remains unclear. In this study, we evaluated a series of natural polymorphisms at positions 328 and 330 with different combinations of adjacent glycosylation sites in the HIV-1 subtype B backbone to address their role...
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