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Article

A stress-free strategy to correct point mutations in patient iPS cells.

Stem cell research - 1 May 2021

Cai Jingli, Kropf Elizabeth, Hou Ya-Ming, Iacovitti Lorraine

Abstract excerpt

When studying patient specific induced pluripotent stem cells (iPS cells) as a disease model, the ideal control is an isogenic line that has corrected the point mutation, instead of iPS cells from siblings or other healthy subjects. However, repairing a point mutation in iPS cells even with the newly developed CRISPR-Cas9 technique remains difficult and time-consuming. Here we report a strategy that makes the...

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Identifiers

PMID: 33857832
DOI: 10.1016/j.scr.2021.102332
PMCID: PMC8283763

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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