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Article

Combination of EZH2 inhibitor and BET inhibitor for treatment of diffuse intrinsic pontine glioma

30 Oct 2017

Abstract excerpt

BACKGROUND: Diffuse intrinsic pontine glioma is an infiltrative, often high-grade glioma of the brainstem that is not amenable to surgical resection. The current treatment of DIPG by radiation therapy showed dramatically improvement of patient's condition, however, the tumor recurs rapidly. More and more studies are focused on the genetic and epigenetic drivers of DIPGs, which may provide more and more novel...

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PMID: 29118968
DOI: 10.1186/s13578-017-0184-0

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