Article
Identifying therapeutic drug targets using bidirectional effect genes.
Nature communications - 13 Apr 2021
Estrada Karol, Froelich Steven, Wuster Arthur, Bauer Christopher R, Sterling Teague, Clark Wyatt T, Ru Yuanbin, Trinidad Marena, Nguyen Hong Phuc, Luu Amanda R, Wendt Daniel J, Yogalingam Gouri, Yu Guoying Karen, LeBowitz Jonathan H, Cardon Lon R
Abstract excerpt
Prioritizing genes for translation to therapeutics for common diseases has been challenging. Here, we propose an approach to identify drug targets with high probability of success by focusing on genes with both gain of function (GoF) and loss of function (LoF) mutations associated with opposing effects on phenotype (Bidirectional Effect Selected Targets, BEST). We find 98 BEST genes for a variety of indications....
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