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Article

Septal chondrocyte hypertrophy contributes to midface deformity in a mouse model of Apert syndrome.

Scientific reports - 12 Apr 2021

Kim Bong-Soo, Shin Hye-Rim, Kim Hyun-Jung, Yoon Heein, Cho Young-Dan, Choi Kang-Young, Choi Je-Yong, Kim Woo-Jin, Ryoo Hyun-Mo

Abstract excerpt

Midface hypoplasia is a major manifestation of Apert syndrome. However, the tissue component responsible for midface hypoplasia has not been elucidated. We studied mice with a chondrocyte-specific Fgfr2S252W mutation (Col2a1-cre; Fgfr2S252W/+) to investigate the effect of cartilaginous components in midface hypoplasia of Apert syndrome. In Col2a1-cre; Fgfr2S252W/+ mice, skull shape was normal at birth, but...

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Identifiers

PMID: 33846505
DOI: 10.1038/s41598-021-87260-5
PMCID: PMC8041873

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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