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Article

A highly prevalent SINE mutation in the myostatin (MSTN) gene promoter is associated with low circulating myostatin concentration in Thoroughbred racehorses.

Scientific reports - 12 Apr 2021

O'Hara Victoria, Cowan Amélie, Riddell Dominique, Massey Claire, Martin John, Piercy Richard J

Abstract excerpt

Horse racing is a popular and financially important industry worldwide and researchers and horse owners are interested in genetic and training influences that maximise athletic performance. An association has been found between the presence of a short interspersed nuclear element (SINE) mutation in the myostatin (MSTN) gene promoter and optimal race distance in Thoroughbred horses. There is previous laboratory...

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Identifiers

PMID: 33846367
DOI: 10.1038/s41598-021-86783-1
PMCID: PMC8041750

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A highly prevalent SINE mutation in the myostatin (MSTN) gene promoter is associated with low circulating myostatin concentration in Thoroughbred racehorses.PMID 33846367Read ↗

A Highly Prevalent SINE Mutation in The Myostatin (MSTN) Gene Promoter Is Associated With Low Circulating Myostatin Concentration in Thoroughbred RacehorsesSemantic proximity Read ↗

Generation of myostatin edited horse embryos using CRISPR/Cas9 technology and somatic cell nuclear transfer.Semantic proximity Read ↗

Putative regulation mechanism for the MSTN gene by a CpG island generated by the SINE marker Ins227bp.Semantic proximity Read ↗

A sequence polymorphism in MSTN predicts sprinting ability and racing stamina in thoroughbred horses.Semantic proximity Read ↗

Analysis of horse myostatin gene and identification of single nucleotide polymorphisms in breeds of different morphological types.Semantic proximity Read ↗

Characterization of Partial Sequence of Myostatin Gene Exon 2 along with SNP detection in Indian Horse Breeds (Equus caballus).Semantic proximity Read ↗

Genetic variations in the myostatin gene (MSTN) in New Zealand sheep breeds.Semantic proximity Read ↗

MSTN genotype (g.66493737C/T) association with speed indices in Thoroughbred racehorses.Semantic proximity Read ↗

Single nucleotide polymorphisms of myostatin gene in Chinese domestic horses.Semantic proximity Read ↗

A genome-wide SNP-association study confirms a sequence variant (g.66493737C>T) in the equine myostatin (MSTN) gene as the most powerful predictor of optimum racing distance for Thoroughbred racehorses.Semantic proximity Read ↗

Sequence variants at the myostatin gene locus influence the body composition of Thoroughbred horses.Semantic proximity Read ↗

Haplotype diversity in the equine myostatin gene with focus on variants associated with race distance propensity and muscle fiber type proportions.Semantic proximity Read ↗

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