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Compound FC-10696 Inhibits Egress of Marburg Virus

13 Apr 2021

Abstract excerpt

Marburg virus (MARV) VP40 protein (mVP40) directs egress and spread of MARV, in part, by recruiting specific host WW domain-containing proteins via its conserved PPxY late (L) domain motif to facilitate efficient virus-cell separation. We reported previously that small-molecule compounds targeting the viral PPxY/host WW domain interaction inhibited VP40-mediated egress and spread. Here, we report on the antiviral...

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PMID: 33846137
DOI: 10.1128/aac.00086-21

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