Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Small-Molecule Probes Targeting the Viral PPxY-Host Nedd4 Interface Block Egress of a Broad Range of RNA Viruses

17 Apr 2014

Abstract excerpt

UNLABELLED: Budding of filoviruses, arenaviruses, and rhabdoviruses is facilitated by subversion of host proteins, such as Nedd4 E3 ubiquitin ligase, by viral PPxY late (L) budding domains expressed within the matrix proteins of these RNA viruses. As L domains are important for budding and are highly conserved in a wide array of RNA viruses, they represent potential broad-spectrum targets for the development of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to interferon and immune responses
Share to Viral Infections and Outbreaks Research
Share to Viral Infections and Vectors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 24741084
DOI: 10.1128/jvi.00591-14

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Small-Molecule Probes Targeting the Viral PPxY-Host Nedd4 Interface Block Egress of a Broad Range of RNA VirusesPMID 24741084Read ↗

ITCH E3 Ubiquitin Ligase Interacts with Ebola Virus VP40 To Regulate BuddingSemantic proximity Read ↗

Regulation of Marburg virus (MARV) budding by Nedd4.1: a different WW domain of Nedd4.1 is critical for binding to MARV and Ebola virus VP40Semantic proximity Read ↗

A Host-Oriented Inhibitor of Junin Argentine Hemorrhagic Fever Virus EgressSemantic proximity Read ↗

ALIX Rescues Budding of a Double PTAP/PPEY L-Domain Deletion Mutant of Ebola VP40: A Role for ALIX in Ebola Virus EgressSemantic proximity Read ↗

Host and Viral Proteins Modulating Ebola and Marburg Virus EgressSemantic proximity Read ↗

Compound FC-10696 Inhibits Egress of Marburg VirusSemantic proximity Read ↗

Chaperone-Mediated Autophagy Protein BAG3 Negatively Regulates Ebola and Marburg VP40-Mediated EgressSemantic proximity Read ↗

Nedd4 Regulates Egress of Ebola Virus-Like Particles from Host CellsSemantic proximity Read ↗

Conserved Filovirus Proteins as Targets of Broad-Spectrum AntiviralsSemantic proximity Read ↗

Ubiquitin Ligase WWP1 Interacts with Ebola Virus VP40 To Regulate EgressSemantic proximity Read ↗

Ebolavirus Entry: From Molecular Characterization to Drug DiscoverySemantic proximity Read ↗

Viral Late DomainsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.