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Article

Identification of critical amino acid residues in the regulatory N-terminal domain of PMEL.

Scientific reports - 8 Apr 2021

Mitchell Susan M, Graham Morven, Liu Xinran, Leonhardt Ralf M

Abstract excerpt

The pigment cell-specific protein PMEL forms a functional amyloid matrix in melanosomes onto which the pigment melanin is deposited. The amyloid core consists of a short proteolytic fragment, which we have termed the core-amyloid fragment (CAF) and perhaps additional parts of the protein, such as the PKD domain. A highly O-glycosylated repeat (RPT) domain also derived from PMEL proteolysis associates with the...

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Identifiers

PMID: 33833328
DOI: 10.1038/s41598-021-87259-y
PMCID: PMC8032716

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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