Article
Mutations in TDP-43 link glycine-rich domain functions to amyotrophic lateral sclerosis.
Human molecular genetics - 15 Oct 2009
Pesiridis G Scott, Lee Virginia M-Y, Trojanowski John Q
Abstract excerpt
Amyotrophic lateral sclerosis (ALS) is the most common adult motor neuron disease that affects approximately 2/100,000 individuals each year worldwide. Patients with ALS suffer from rapidly progressive degeneration of motor neurons ultimately leading to death. The major pathological features observed in post-mortem tissue from patients with ALS are motor neuron loss, cortical spinal tract degeneration, gliosis...
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