Article
An antipathogenic compound that targets the OxyR peroxide sensor in Pseudomonas aeruginosa.
Journal of medical microbiology - 1 Apr 2021
Oh Hyo-Young, Jalde Shivakumar S, Chung In-Young, Yoo Yeon-Ji, Jang Hye-Jeong, Choi Hyun-Kyung, Cho You-Hee
Abstract excerpt
Introduction. Antipathogenic or antivirulence strategy is to target a virulence pathway that is dispensable for growth, in the hope to mitigate the selection for drug resistance.Hypothesis/Gap Statment. Peroxide stress responses are one of the conserved virulence pathways in bacterial pathogens and thus good targets for antipathogenic strategy.Aim. This study aims to identify a new chemical compound that targets...
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