Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Identification of PIK3CA multigene mutation patterns associated with superior prognosis in stomach cancer.

BMC cancer - 7 Apr 2021

Yu Yu, Xie Zhuoming, Zhao Mingxin, Lian Xiaohua

Abstract excerpt

BACKGROUND: PIK3CA is the second most frequently mutated gene in cancers and is extensively studied for its role in promoting cancer cell resistance to chemotherapy or targeted therapy. However, PIK3CA functions have mostly been investigated at a lower-order genetic level, and therapeutic strategies targeting PIK3CA mutations have limited effects. Here, we explore crucial factors interacting with PIK3CA mutations...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biomarkers, Tumor
Share to Class I Phosphatidylinositol 3-Kinases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutation

Share to Prognosis

Share to Stomach Neoplasms

Share to Survival Analysis

Source

Open in PubMed Open full text

Identifiers

PMID: 33827485
DOI: 10.1186/s12885-021-08115-w
PMCID: PMC8028071

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification of PIK3CA multigene mutation patterns associated with superior prognosis in stomach cancer.PMID 33827485Read ↗

Pathway Mutation Accumulate Perturbation Score: A prognostic and predictive biomarker for immunotherapy in advanced gastric cancer.Semantic proximity Read ↗

Molecular characteristics of advanced colorectal cancer and multi-hit PIK3CA mutations.Semantic proximity Read ↗

Landscapes of synchronous multiple primary cancers detected by next-generation sequencing.Semantic proximity Read ↗

Morin Modulates Key Targets and Pathways Associated with Gastric Cancer: Network Pharmacology, Molecular Docking, Molecular Dynamics, ADMET, and In‑Vitro AnalysisSemantic proximity Read ↗

Mutational landscape of pan-cancer patients with PIK3CA alterations in Chinese population.Semantic proximity Read ↗

Prognostic significance of actionable next-generation sequencing multigene panel in esophageal cancer treatment.Semantic proximity Read ↗

PIK3CA mutations confer resistance to first-line chemotherapy in colorectal cancer.Semantic proximity Read ↗

The role of PIK3CA gene mutations in colorectal cancer and the selection of treatment strategiesSemantic proximity Read ↗

The impact of heterogeneity in phosphoinositide 3-kinase pathway in human cancer and possible therapeutic treatments.Semantic proximity Read ↗

PIK3CA mutations are associated with increased tumor aggressiveness and Akt activation in gastric cancerSemantic proximity Read ↗

Therapeutic targets of gastric cancer explored under endogenous network modeling of clinical dataSemantic proximity Read ↗

Artificial Intelligence-Guided Molecular Determinants of PI3K Pathway Alterations in Early-Onset Colorectal Cancer Among High-Risk Groups Receiving FOLFOXSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.