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Article

Multi-gene custom panels for the characterisation of metastatic colorectal carcinoma in clinical practice: express the role of PIK3CA mutations.

Journal of clinical pathology - 1 Jul 2022

de Biase Dario, Malapelle Umberto, De Leo Antonio, Maloberti Thais, Visani Michela, Pisapia Pasquale, Acquaviva Giorgia, Pepe Francesco, Russo Gianluca, Iaccarino Antonino, Pession Annalisa, Tallini Giovanni, Troncone Giancarlo

Abstract excerpt

AIMS: In metastatic colorectal carcinomas (mCRC), RAS/RAF genes mutations are first tested to determine the eligibility for anti-EGFR (Epidermal Growth Factor Receptor) therapy in combination with conventional cytotoxic agents. Recent advancements in next-generation sequencing (NGS) have highlighted the potential of multi-gene panels. This multi-gene analysis may provide useful information for the molecular...

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PMID: 33820865
DOI: 10.1136/jclinpath-2021-207468

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