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Integrated analysis of the genomic and transcriptional profile of high-grade gliomas in different age groups.

Clinical immunology (Orlando, Fla.) - 1 May 2021

Yang Pei, Liu Qi, Tao Rui, Shan Xia, Huang Ruoyu, Wang Kuanyu, Wang Jiangfei

Abstract excerpt

BACKGROUND: Age is a powerful prognostic factor of high-grade glioma (HGG). However, the underlying genetic mechanisms of the discrepant prognosis among different age groups remain elusive. METHODS: A total of 953 and 559 HGG patients from The Cancer Genome Atlas (TCGA) and Chinese Glioma Genome Atlas (CGGA) cohorts were enrolled and assigned as young, intermediate, elderly groups. The data of clinicopathological...

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PMID: 33819578
DOI: 10.1016/j.clim.2021.108719

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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