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Article

A mutational approach to dissect the functional role of the putative CFTR "PTM-CODE".

Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society - 1 Sept 2021

D'Amore Claudio, Borgo Christian, Salvi Mauro

Abstract excerpt

Deletion of Phe at position 508 (F508del) in CFTR is the commonest cause of Cystic Fibrosis; this mutation affects the fate of the protein, since most of the F508del-CFTR is retained in the endoplasmic reticulum, ubiquitylated and degraded. CFTR is subjected to different post-translational modifications (PTMs) and the possibility to modulate these PTMs has been suggested as a potential therapeutic strategy for...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 33814322
DOI: 10.1016/j.jcf.2021.03.010

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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