Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Can correcting the ΔF508-CFTR proteostasis-defect rescue CF lung disease?

Current molecular medicine - 1 Aug 2012

Valle C W, Vij N

Abstract excerpt

Protein homeostasis (proteostasis) generates and maintains individual proteins in their folded and functional-competent states. The components of the cellular proteostasis machinery also dictate the functional lifetime of a protein by constantly regulating its conformation, concentration and subcellular location. The autosomal recessive disease cystic fibrosis (CF) is caused by a proteostasis-defect in CF...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cystic Fibrosis
Share to Cystic Fibrosis Transmembrane Conductance Regulator
Share to CFTR gene

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lung Diseases

Share to Mutation

Source

Identifiers

PMID: 22697346
DOI: 10.2174/156652412801318773

Genes

CFTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Can correcting the ΔF508-CFTR proteostasis-defect rescue CF lung disease?PMID 22697346Read ↗

Adapting Proteostasis and Autophagy for Controlling the Pathogenesis of Cystic Fibrosis Lung DiseaseSemantic proximity Read ↗

Transcriptomic and Proteostasis Networks of CFTR and the Development of Small Molecule Modulators for the Treatment of Cystic Fibrosis Lung Disease.Semantic proximity Read ↗

Emergent properties of proteostasis in managing cystic fibrosis.Semantic proximity Read ↗

Proteostasis Regulators in Cystic Fibrosis: Current Development and Future Perspectives.Semantic proximity Read ↗

Disease-relevant proteostasis regulation of cystic fibrosis transmembrane conductance regulator.Semantic proximity Read ↗

CFTR Folding: From Structure and Proteostasis to Cystic Fibrosis Personalized Medicine.Semantic proximity Read ↗

Regulation of CFTR Biogenesis by the Proteostatic Network and Pharmacological Modulators.Semantic proximity Read ↗

Therapeutic approaches to CFTR dysfunction: From discovery to drug development.Semantic proximity Read ↗

Alpha 1-Antitrypsin Deficiency: A Disorder of Proteostasis-Mediated Protein Folding and Trafficking PathwaysSemantic proximity Read ↗

CFTR: folding, misfolding and correcting the ΔF508 conformational defect.Semantic proximity Read ↗

Proteomics uncovering possible key players in F508del-CFTR processing and trafficking.Semantic proximity Read ↗

Protein Processing and Inflammatory Signaling in Cystic Fibrosis: Challenges and Therapeutic StrategiesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.