Article
Molecular Characteristics of Lymphocyte-predominant Triple-negative Breast Cancer.
Anticancer research - 1 Apr 2021
Sasaki Ritsuko, Horimoto Yoshiya, Yanai Yuka, Kurisaki-Arakawa Aiko, Arakawa Atsushi, Nakai Katsuya, Saito Mitsue, Saito Tsuyoshi
Abstract excerpt
BACKGROUND/AIM: Tumor-infiltrating lymphocytes (TILs) are considered a prognostic marker for triple-negative breast cancer (TNBC). Immune checkpoint inhibitor (ICI)-based treatments are more effective for tumors with PD-L1-positive TILs, suggesting crucial roles of TILs in the local tumor immunity. However, factors attracting TILs are still largely unknown. Focusing on tumor antigenicity, we examined TNBC samples...
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