All HPV-negative head and neck cancers are not the same: Analysis of the TCGA dataset reveals that anatomical sites have distinct mutation, transcriptome, hypoxia, and tumor microenvironment profiles.

doi:10.1016/j.oraloncology.2021.105260

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All HPV-negative head and neck cancers are not the same: Analysis of the TCGA dataset reveals that anatomical sites have distinct mutation, transcriptome, hypoxia, and tumor microenvironment profiles.

Oral oncology - 1 May 2021

Kim Hugh Andrew Jinwook, Zeng Peter Y F, Shaikh Mushfiq Hassan, Mundi Neil, Ghasemi Farhad, Di Gravio Eric, Khan Halema, MacNeil Danielle, Khan Mohammed Imran, Patel Krupal, Mendez Adrian, Yoo John, Fung Kevin, Lang Pencilla, Palma David A, Mymryk Joe S, Barrett John W, Boutros Paul C, Nichols Anthony C

Abstract excerpt

PURPOSE: Head and neck squamous cell carcinoma (HNSCC) affects various anatomical sites, which often dictates whether the cancer is managed with primary surgery or radiation. This study aimed to assess differences in single nucleotide variation (SNV), copy number, mRNA abundance, methylation, and tumor microenvironment (TME) between HPV-negative oral cavity (OC), oropharyngeal (OPC), hypopharyngeal (HPC), and...

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PMID: 33725617
DOI: 10.1016/j.oraloncology.2021.105260

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