Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The mechanical phenotypic plasticity of melanoma cell: an emerging driver of therapy cross-resistance

11 Feb 2023

Abstract excerpt

Advanced cutaneous melanoma is the deadliest form of skin cancer and one of the most aggressive human cancers. Targeted therapies (TT) against BRAF mutated melanoma and immune checkpoints blockade therapies (ICB) have been a breakthrough in the treatment of metastatic melanoma. However, therapy-driven resistance remains a major hurdle in the clinical management of the metastatic disease. Besides shaping the tumor...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Cells and Metastasis
Share to Cell Adhesion Molecules Research
Share to Cellular Mechanics and Interactions

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 36774337
DOI: 10.1038/s41389-023-00452-8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The mechanical phenotypic plasticity of melanoma cell: an emerging driver of therapy cross-resistancePMID 36774337Read ↗

BRAF V600-Mutated Metastatic Melanoma and Targeted Therapy Resistance: An Update of the Current KnowledgeSemantic proximity Read ↗

Role of extracellular matrix architecture and signaling in melanoma therapeutic resistanceSemantic proximity Read ↗

A Feed-Forward Mechanosignaling Loop Confers Resistance to Therapies Targeting the MAPK Pathway in BRAF-Mutant Melanoma.Semantic proximity Read ↗

Influence of Tumor Microenvironment and Fibroblast Population Plasticity on Melanoma Growth, Therapy Resistance and ImmunoescapeSemantic proximity Read ↗

Exploring the Complex and Multifaceted Interplay between Melanoma Cells and the Tumor MicroenvironmentSemantic proximity Read ↗

Phenotype Switching and the Melanoma Microenvironment; Impact on Immunotherapy and Drug Resistance.Semantic proximity Read ↗

The Role of Melanoma Cell-Stroma Interaction in Cell Motility, Invasion, and MetastasisSemantic proximity Read ↗

Therapeutic resistance and susceptibility is shaped by cooperative multi-compartment tumor adaptationSemantic proximity Read ↗

Phenotypic tumour cell plasticity as a resistance mechanism and therapeutic target in melanoma.Semantic proximity Read ↗

Pre-clinical modeling of cutaneous melanomaSemantic proximity Read ↗

Targeting DDR1 and DDR2 overcomes matrix-mediated melanoma cell adaptation to BRAF-targeted therapySemantic proximity Read ↗

RNA-seq Characterization of Melanoma Phenotype Switch in 3D Collagen after p38 MAPK Inhibitor Treatment.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.