Article
Loss of col8a1a function during zebrafish embryogenesis results in congenital vertebral malformations.
Developmental biology - 1 Feb 2014
Gray Ryan S, Wilm Thomas P, Smith Jeff, Bagnat Michel, Dale Rodney M, Topczewski Jacek, Johnson Stephen L, Solnica-Krezel Lilianna
Abstract excerpt
Congenital vertebral malformations (CVM) occur in 1 in 1000 live births and in many cases can cause spinal deformities, such as scoliosis, and result in disability and distress of affected individuals. Many severe forms of the disease, such as spondylocostal dystostosis, are recessive monogenic traits affecting somitogenesis, however the etiologies of the majority of CVM cases remain undetermined. Here we...
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