Human Papilloma Virus 18-Positive Submucosal Small Cell Neuroendocrine Carcinoma of the Vagina: An Immunohistochemical and Genomic Study.

doi:10.1177/10668969211007569

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Article

Human Papilloma Virus 18-Positive Submucosal Small Cell Neuroendocrine Carcinoma of the Vagina: An Immunohistochemical and Genomic Study.

International journal of surgical pathology - 1 Dec 2021

Kitazono Ikumi, Akahane Toshiaki, Sakihama Mika, Yanazume Shintaro, Matsushita Michiko, Tabata Kazuhiro, Kobayashi Yusuke, Kobayashi Hiroaki, Umekita Yoshihisa, Tanimoto Akihide

Abstract excerpt

Primary vaginal neuroendocrine carcinoma (NEC) is extremely rare among female genital tract tumors. Here, we report 2 cases of vaginal small cell NEC (SCNEC) using immunohistochemistry and next-generation sequencing (NGS) analysis. The 2 patients were in their mid-to-late 70s, presented with abnormal vaginal bleeding and had a vaginal submucosal mass. The biopsied or resected tumors showed a typical...

Topics

Aged
Biomarkers, Tumor
Carcinoma, Neuroendocrine
Carcinoma, Small Cell
DNA Mutational Analysis
Female
Genomics
High-Throughput Nucleotide Sequencing
Human papillomavirus 18

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Immunohistochemistry

Mutation

Neurofibromin 1

Papillomavirus Infections

Receptors, Androgen

Vagina

Vaginal Neoplasms

Source

Open in PubMed

Identifiers

PMID: 33792412
DOI: 10.1177/10668969211007569

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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