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Article

DECO: a framework for jointly analyzing de novo and rare case/control variants, and biological pathways.

Briefings in bioinformatics - 2 Sept 2021

Nguyen Tan-Hoang, He Xin, Brown Ruth C, Webb Bradley T, Kendler Kenneth S, Vladimirov Vladimir I, Riley Brien P, Bacanu Silviu-Alin

Abstract excerpt

MOTIVATION: Rare variant-based analyses are beginning to identify risk genes for neuropsychiatric disorders and other diseases. However, the identified genes only account for a fraction of predicted causal genes. Recent studies have shown that rare damaging variants are significantly enriched in specific gene-sets. Methods which are able to jointly model rare variants and gene-sets to identify enriched gene-sets...

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Identifiers

PMID: 33791774
DOI: 10.1093/bib/bbab067
PMCID: PMC8425460

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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