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Article

Effect of Metformin in Combination With Trametinib and Paclitaxel on Cell Survival and Metastasis in Melanoma Cells.

Anticancer research - 1 Mar 2021

Lee Youngki, Park Deokbae

Abstract excerpt

BACKGROUND/AIM: Despite clinical benefit from treatment with dabrafenib and trametinib in melanoma patients with BRAF mutations, half relapse within months and one-third are unresponsive to treatment. We evaluated the anticancer potential of metformin in combination with trametinib plus paclitaxel, against four melanoma cell lines. MATERIALS AND METHODS: Metformin with trametinib and paclitaxel was tested for...

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Identifiers

PMID: 33788730
DOI: 10.21873/anticanres.14896

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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