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Metformin Treatment Suppresses Melanoma Cell Growth and Motility Through Modulation of microRNA Expression

11 Feb 2019

Abstract excerpt

Melanoma is a highly aggressive cancer with high mortality in advanced stages.Metformin is an oral biguanide drug used for diabetes and has demonstrated positive effects oncancer prevention and treatment. Herein, we found that metformin significantly suppressedmelanoma cancer cell motility and growth through inducing cell cycle arrest at the G2/M phase andpromoting cell apoptosis. Using the next-generation...

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PMID: 30754729
DOI: 10.3390/cancers11020209

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