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Article

Characterization of a Respiratory Syncytial Virus L Protein Inhibitor

29 Apr 2014

Abstract excerpt

The respiratory syncytial virus (RSV) L protein is a viral RNA-dependent RNA polymerase that contains multiple enzyme activities required for RSV replication. The RSV L inhibitors described in literature are limited by their cytotoxicity or the lack of RSV B subtype coverage. Here, we characterize a new RSV L inhibitor with strong antiviral activity against both RSV A and B subtypes and no detectable...

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PMID: 24777090
DOI: 10.1128/aac.02540-14

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