Mutations in BRCA1/2 and Other Panel Genes in Patients With Metastatic Breast Cancer -Association With Patient and Disease Characteristics and Effect on Prognosis.

doi:10.1200/JCO.20.01200

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Mutations in BRCA1/2 and Other Panel Genes in Patients With Metastatic Breast Cancer -Association With Patient and Disease Characteristics and Effect on Prognosis.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 20 May 2021

Fasching Peter A, Yadav Siddhartha, Hu Chunling, Wunderle Marius, Häberle Lothar, Hart Steven N, Rübner Matthias, Polley Eric C, Lee Kun Y, Gnanaolivu Rohan D, Hadji Peyman, Hübner Hanna, Tesch Hans, Ettl Johannes, Overkamp Friedrich, Lux Michael P, Ekici Arif B, Volz Bernhard, Uhrig Sabrina, Lüftner Diana, Wallwiener Markus, Müller Volkmar, Belleville Erik, Untch Michael, Kolberg Hans-Christian, Beckmann Matthias W, Reis André, Hartmann Arndt, Janni Wolfgang, Wimberger Pauline, Taran Florin-Andrei, Fehm Tanja N, Wallwiener Diethelm, Brucker Sara Y, Schneeweiss Andreas, Hartkopf Andreas D, Couch Fergus J

Abstract excerpt

PURPOSE: Among patients with metastatic breast cancer (mBC), the frequency of germline mutations in cancer susceptibility genes and the clinical relevance of these mutations are unclear. In this study, a prospective cohort of patients with mBC was used to determine mutation rates for breast cancer (BC) predisposition genes, to evaluate the clinical characteristics of patients with mutations, and to assess the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to BRCA gene mutations in cancer

Share to Breast Cancer Treatment Studies

Share to Breast Neoplasms

Share to Genes, BRCA1

Share to Genes, BRCA2

Share to Mutation

Share to Neoplasm Metastasis

Share to Prognosis

Source

Open in PubMed Open full text

Identifiers

PMID: 33780288
DOI: 10.1200/JCO.20.01200
PMCID: PMC8274805

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutations in BRCA1/2 and Other Panel Genes in Patients With Metastatic Breast Cancer -Association With Patient and Disease Characteristics and Effect on Prognosis.PMID 33780288Read ↗

Impact of multi-gene mutational profiling on clinical trial outcomes in metastatic breast cancer.Semantic proximity Read ↗

Other Primary Malignancies in Patients with Breast Cancer Who Undergo Germline Panel Testing.Semantic proximity Read ↗

Characterizations of Cancer Gene Mutations in Chinese Metastatic Breast Cancer PatientsSemantic proximity Read ↗

Survival outcomes of metastatic breast cancer patients by germline BRCA1/2 status in a large multicenter real‐world databaseSemantic proximity Read ↗

Outcome of metastatic breast cancer in selected women with or without deleterious BRCA mutations.Semantic proximity Read ↗

Identification of Somatically Acquired BRCA1/2 Mutations by cfDNA Analysis in Patients with Metastatic Breast Cancer.Semantic proximity Read ↗

Genomic profiling using the UltraSEEK panel identifies discordancy between paired primary and breast cancer brain metastases and an association with brain metastasis-free survival.Semantic proximity Read ↗

Genetic Alterations Detected by Circulating Tumor DNA in HER2-Low Metastatic Breast Cancer.Semantic proximity Read ↗

Spectrum of breast cancer metastasis in BRCA1 mutation carriers: highly increased incidence of brain metastasesSemantic proximity Read ↗

BRCA1 Mutations Associated With Increased Risk of Brain Metastases in Breast Cancer: A 1: 2 Matched-pair Analysis.Semantic proximity Read ↗

Prognostic Value of the TP53 Mutation Location in Metastatic Breast Cancer as Detected by Next-Generation SequencingSemantic proximity Read ↗

Discordance of PIK3CA and TP53 Mutations Between Breast Cancer Brain Metastases and Matched Primary TumorsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.