Article
Associations of TNFA, IL17A, and RORC mRNA expression levels in peripheral blood leukocytes with obesity-related asthma in adolescents.
Clinical immunology (Orlando, Fla.) - 1 Aug 2021
Leija-Martínez José J, Del-Río-Navarro Blanca E, Sanchéz-Muñoz Fausto, Muñoz-Hernández Onofre, Hong Enrique, Giacoman-Martínez Abraham, Romero-Nava Rodrigo, Patricio-Román Karla L, Hall-Mondragon Margareth S, Espinosa-Velazquez Dario, Villafaña Santiago, Huang Fengyang
Abstract excerpt
Obesity is associated with a unique non-T2 asthma phenotype, characterised by a Th17 immune response. Retinoid-related orphan receptor C (RORC) is the master transcription factor for Th17 polarisation. We investigated the association of TNFA, IL17A, and RORC mRNA expression levels with the non-T2 phenotype. We conducted a cross-sectional study in adolescents, subdivided as follows: healthy (HA), allergic asthma...
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