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Article

Genetic association of ERAP1 and ERAP2 with eclampsia and preeclampsia in northeastern Brazilian women.

Scientific reports - 24 Mar 2021

Ferreira Leonardo Capistrano, Gomes Carlos Eduardo Maia, Duggal Priya, De Paula Holanda Ingrid, de Lima Amanda Samara, do Nascimento Paulo Ricardo Porfírio, Jeronimo Selma Maria Bezerra

Abstract excerpt

The clinical spectrum of hypertensive disorders of pregnancy (HDP) is determined by the interplay between environmental and genetic factors, most of which remains unknown. ERAP1, ERAP2 and LNPEP genes code for multifunctional aminopeptidases involved with antigen processing and degradation of small peptides such as angiotensin II (Ang II), vasopressin and oxytocin. We aimed to test for associations between...

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Identifiers

PMID: 33762660
DOI: 10.1038/s41598-021-86240-z
PMCID: PMC7990956

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