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A Case-Control Study of the APELA Gene and Hypertensive Disorders of Pregnancy.

Medicina (Kaunas, Lithuania) - 26 Apr 2022

Shimada Naomi, Nakayama Tomohiro, Umemura Hiroshi, Kawana Kei, Yamamoto Tatsuo, Uchigasaki Seisaku

Abstract excerpt

Hypertensive disorders of pregnancy (HDPs) are believed to comprise a group of multifactorial genetic diseases. Recently, it was reported that APELA-knockout mice exhibited HDP-like symptoms, including proteinuria and elevated blood pressure due to defective placental angiogenesis. The aim of the present study is to determine the associations between HDPs and single-nucleotide variants or haplotypes in the human...

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Identifiers

PMID: 35630008
DOI: 10.3390/medicina58050591
PMCID: PMC9146499

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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