Disentangling the Contribution of Each Descriptive Characteristic of Every Single Mutation to Its Functional Effects.

Abstract excerpt

Mutational effects predictions continue to improve in accuracy as advanced artificial intelligence (AI) algorithms are trained on exhaustive experimental data. The next natural questions to ask are if it is possible to gain insights into which attribute of the mutation contributes how much to the mutational effects and if one can develop universal rules for mapping the descriptors to mutational effects. In this...

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