Development of a system combining comprehensive genotyping and organoid cultures for identifying and testing genotype-oriented personalised medicine for pancreatobiliary cancers.

doi:10.1016/j.ejca.2021.01.047

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Development of a system combining comprehensive genotyping and organoid cultures for identifying and testing genotype-oriented personalised medicine for pancreatobiliary cancers.

European journal of cancer (Oxford, England : 1990) - 1 May 2021

Shiihara Masahiro, Ishikawa Tomohiko, Saiki Yuriko, Omori Yuko, Hirose Katsuya, Fukushige Shinichi, Ikari Naoki, Higuchi Ryota, Yamamoto Masakazu, Morikawa Takanori, Nakagawa Kei, Hayashi Hiroki, Mizuma Masamichi, Ohtsuka Hideo, Motoi Fuyuhiko, Unno Michiaki, Okamura Yasunobu, Kinoshita Kengo, Furukawa Toru

Abstract excerpt

BACKGROUND: Pancreatobiliary cancer is a highly aggressive tumour with a dismal prognosis. Personalised medicine represents a promising and effective therapeutic approach for this intractable disease. In this study, we aimed to establish a system for identifying and testing genotype-oriented targeted drugs for pancreatobiliary cancers by combining exome sequencing and organoid culture of primary tumours. METHODS:...

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PMID: 33752134
DOI: 10.1016/j.ejca.2021.01.047

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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