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Article

Ribosome biogenesis protein Urb2 regulates hematopoietic stem cells development via P53 pathway in zebrafish.

Biochemical and biophysical research communications - 4 Mar 2018

Cai Pengcheng, Mao Xiaoyu, Zhao Jieqiong, Luo Lingfei

Abstract excerpt

Ribosome biogenesis is a significant process in cells. Dysfunction in this process will result in the defects of protein synthesis and consequently cause the development of specific diseases called ribosomopathies. Mutations in ribosome biogenesis protein Rps19, Rpl5, or Rpl11 can lead to hematopoietic defects in human, thus triggering the disease Diamond Blackfan anemia. However, the regulatory mechanisms of...

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PMID: 29470984
DOI: 10.1016/j.bbrc.2018.02.153

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