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Article

Cross-linking peptide and repurposed drugs inhibit both entry pathways of SARS-CoV-2

9 Mar 2021

Abstract excerpt

Up to date, effective antivirals have not been widely available for treating COVID-19. In this study, we identify a dual-functional cross-linking peptide 8P9R which can inhibit the two entry pathways (endocytic pathway and TMPRSS2-mediated surface pathway) of SARS-CoV-2 in cells. The endosomal acidification inhibitors (8P9R and chloroquine) can synergistically enhance the activity of arbidol, a spike-ACE2 fusion...

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PMID: 33750821
DOI: 10.1038/s41467-021-21825-w

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