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A trifunctional peptide broadly inhibits SARS-CoV-2 Delta and Omicron variants in hamsters

30 Jun 2022

Abstract excerpt

The emergence of highly transmissible SARS-CoV-2 variants has led to the waves of the resurgence of COVID-19 cases. Effective antivirals against variants are required. Here we demonstrate that a human-derived peptide 4H30 has broad antiviral activity against the ancestral virus and four Variants of Concern (VOCs) in vitro. Mechanistically, 4H30 can inhibit three distinct steps of the SARS-CoV-2 life cycle....

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PMID: 35768416
DOI: 10.1038/s41421-022-00428-9

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