Article
A Comprehensive Analysis of Genomics and Metagenomics in a Heterozygote Familial Hypercholesterolemia Family.
Frontiers in cellular and infection microbiology - 1 Jan 2021
Liu Honghong, Jin Ye, Tian Ran, Feng Siqin, Zhang Shuyang, Zhang Chenhong
Abstract excerpt
Familial hypercholesterolemia (FH) is an inherited rare disease leading to markedly elevated low-density lipoprotein cholesterol (LDL-C) levels and increased risk for cardiovascular event. Gut microbiota has been implicated as a pivotal contributing factor in hyperlipidemia, however, its role in FH remains elusive. We performed whole-exome and metagenomics sequencing on a family with 22 members in which...
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