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Autophagy degrades immunogenic endogenous retroelements induced by 5-azacytidine in acute myeloid leukemia

16 Apr 2024

Abstract excerpt

Abstract The hypomethylating agent 5-azacytidine (AZA) is the first-line treatment for AML patients unfit for intensive chemotherapy. The effect of AZA results in part from T-cell cytotoxic responses against MHC-I-associated peptides (MAPs) deriving from hypermethylated genomic regions such as cancer-testis antigens (CTAs), or endogenous retroelements (EREs). However, evidence supporting higher ERE MAPs...

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PMID: 38627586
DOI: 10.1038/s41375-024-02250-6

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