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Article

Effects of SLC22A2 808G>T polymorphism and bosutinib concentrations on serum creatinine in patients with chronic myeloid leukemia receiving bosutinib therapy.

Scientific reports - 18 Mar 2021

Abumiya Maiko, Takahashi Naoto, Takahashi Saori, Yoshioka Tomoko, Kameoka Yoshihiro, Miura Masatomo

Abstract excerpt

The purpose of this study was to investigate the effects of SLC22A2 808G>T polymorphism and trough concentrations (C0) of bosutinib on serum creatinine in 28 patients taking bosutinib. At 1, 3, 6, 12, 24, and 36 months after administration, analysis of bosutinib C0 and creatinine was performed at the same time of day. Significant correlations were observed between bosutinib C0 and the change rate of serum...

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Identifiers

PMID: 33737618
DOI: 10.1038/s41598-021-85757-7
PMCID: PMC7973796

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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