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Article

Influence of CYP2C8 polymorphisms on imatinib steady-state trough level in chronic myeloid leukemia and gastrointestinal stromal tumor patients.

Pharmacogenetics and genomics - 1 Jun 2017

Verboom Michiel C, Visser Loes, Kouwen Sander, Swen Jesse J, Diepstraten Jeroen, Posthuma Ward F, Gelderblom Hans, van Lammeren Daniëlle, Wilms Erik B

Abstract excerpt

Imatinib trough levels have been associated with its clinical effects. During chronic use of imatinib, CYP2C8 becomes an important metabolizing enzyme because of cytochrome P450 3A4 (CYP3A4) autoinhibition. Single nucleotide polymorphisms (SNPs) in CYP2C8 may affect imatinib trough levels. This study investigates the effect of common CYP2C8 polymorphisms [*1B (rs7909236), *1C (rs17110453), *3 (rs11572080 and...

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Share to Leukemia, Myelogenous, Chronic, BCR-ABL Positive
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Source

Identifiers

PMID: 28383355
DOI: 10.1097/FPC.0000000000000278

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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